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Role of the Disulfide Bond in Prion Protein Amyloid Formation: A Thermodynamic and Kinetic Analysis
Prion diseases are associated with the structural conversion of prion protein (PrP) to a β-sheet-rich aggregate, PrP(Sc). Previous studies have indicated that a reduction of the disulfide bond linking C179 and C214 of PrP yields an amyloidlike β-rich aggregate in vitro. To gain mechanistic insights...
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| Publicado no: | Biophys J |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984966/ https://ncbi.nlm.nih.gov/pubmed/29490248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.12.031 |
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