Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation

OBJECTIVE: Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage damage and inflammation are also observed in osteoarthritis (OA), we determined the effect of viral overexpression of TSG-6 in ex...

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Dettagli Bibliografici
Pubblicato in:PeerJ
Autori principali: Broeren, Mathijs G.A., Di Ceglie, Irene, Bennink, Miranda B., van Lent, Peter L.E.M., van den Berg, Wim B., Koenders, Marije I., Blaney Davidson, Esmeralda N., van der Kraan, Peter M., van de Loo, Fons A.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: PeerJ Inc. 2018
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984587/
https://ncbi.nlm.nih.gov/pubmed/29868252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.4771
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