Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation

OBJECTIVE: Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage damage and inflammation are also observed in osteoarthritis (OA), we determined the effect of viral overexpression of TSG-6 in ex...

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Udgivet i:PeerJ
Main Authors: Broeren, Mathijs G.A., Di Ceglie, Irene, Bennink, Miranda B., van Lent, Peter L.E.M., van den Berg, Wim B., Koenders, Marije I., Blaney Davidson, Esmeralda N., van der Kraan, Peter M., van de Loo, Fons A.J.
Format: Artigo
Sprog:Inglês
Udgivet: PeerJ Inc. 2018
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984587/
https://ncbi.nlm.nih.gov/pubmed/29868252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.4771
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