PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids

PRDM1 is a tumor suppressor that plays an important role in B and T cell lymphomas. Our previous studies demonstrated that PRDM1β is a p53-response gene in human colorectal cancer cells. However, the function of PRDM1β in colorectal cancer cells and colon tumor organoids is not clear. Here we show t...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Liu, Changlong, Banister, Carolyn E., Weige, Charles C., Altomare, Diego, Richardson, Joseph H., Contreras, Carlo M., Buckhaults, Phillip J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2018
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984534/
https://ncbi.nlm.nih.gov/pubmed/29760071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802902115
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