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Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein
The allosteric interplay between distant functional sites present in a single protein provides for one of the most important regulatory mechanisms in biological systems. While the design of ligand-binding sites into proteins remains challenging, this holds even truer for the coupling of a newly engi...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984491/ https://ncbi.nlm.nih.gov/pubmed/29760101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716666115 |
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