A common antigenic motif recognized by naturally occurring human V(H)5–51/V(L)4–1 anti-tau antibodies with distinct functionalities

Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG(+) memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated V(H)5–51/V(L)4–1 antibodies. One of these, CBTAU-...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Apetri, Adrian, Crespo, Rosa, Juraszek, Jarek, Pascual, Gabriel, Janson, Roosmarijn, Zhu, Xueyong, Zhang, Heng, Keogh, Elissa, Holland, Trevin, Wadia, Jay, Verveen, Hanneke, Siregar, Berdien, Mrosek, Michael, Taggenbrock, Renske, Ameijde, Jeroenvan, Inganäs, Hanna, van Winsen, Margot, Koldijk, Martin H., Zuijdgeest, David, Borgers, Marianne, Dockx, Koen, Stoop, Esther J. M., Yu, Wenli, Brinkman-van der Linden, Els C., Ummenthum, Kimberley, van Kolen, Kristof, Mercken, Marc, Steinbacher, Stefan, de Marco, Donata, Hoozemans, Jeroen J., Wilson, Ian A., Koudstaal, Wouter, Goudsmit, Jaap
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984341/
https://ncbi.nlm.nih.gov/pubmed/29855358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0543-z
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