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PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway
BACKGROUND: Platelets are dynamic effector cells with functions that span hemostatic, thrombotic, and inflammatory continuums. Phosphoinositide-dependent protein kinase 1 (PDK1) regulates protease-activated receptor 4 (PAR4)-induced platelet activation and thrombus formation through glycogen synthas...
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| Publicado en: | J Thromb Haemost |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984143/ https://ncbi.nlm.nih.gov/pubmed/29575487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14005 |
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