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PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway

BACKGROUND: Platelets are dynamic effector cells with functions that span hemostatic, thrombotic, and inflammatory continuums. Phosphoinositide-dependent protein kinase 1 (PDK1) regulates protease-activated receptor 4 (PAR4)-induced platelet activation and thrombus formation through glycogen synthas...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Manne, Bhanu Kanth, Münzer, Patrick, Badolia, Rachit, Walker-Allgaier, Britta, Campbell, Robert A, Middleton, Elizabeth, Weyrich, Andrew S, Kunapuli, Satya P, Borst, Oliver, Rondina, Matthew T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984143/
https://ncbi.nlm.nih.gov/pubmed/29575487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14005
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