Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1α-dependent neuroinflammation in aged rats

Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown. Hypoxia-inducible factor-1α (HIF-1α) is activated by inhaled anesthetics. The aim of the present study was to...

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Vydáno v:Mol Med Rep
Hlavní autoři: Cao, Yiyun, Li, Zhengqian, Ma, Lijun, Ni, Cheng, Li, Lunxu, Yang, Ning, Shi, Chengmei, Guo, Xiangyang
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983961/
https://ncbi.nlm.nih.gov/pubmed/29620198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.8850
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