Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1α-dependent neuroinflammation in aged rats

Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown. Hypoxia-inducible factor-1α (HIF-1α) is activated by inhaled anesthetics. The aim of the present study was to...

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Veröffentlicht in:Mol Med Rep
Hauptverfasser: Cao, Yiyun, Li, Zhengqian, Ma, Lijun, Ni, Cheng, Li, Lunxu, Yang, Ning, Shi, Chengmei, Guo, Xiangyang
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2018
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983961/
https://ncbi.nlm.nih.gov/pubmed/29620198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.8850
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