Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1α-dependent neuroinflammation in aged rats

Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown. Hypoxia-inducible factor-1α (HIF-1α) is activated by inhaled anesthetics. The aim of the present study was to...

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Publicado no:Mol Med Rep
Main Authors: Cao, Yiyun, Li, Zhengqian, Ma, Lijun, Ni, Cheng, Li, Lunxu, Yang, Ning, Shi, Chengmei, Guo, Xiangyang
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983961/
https://ncbi.nlm.nih.gov/pubmed/29620198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.8850
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