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Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function

BACKGROUND: Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease in the presence of chronic kidney disease due to an accumulation of reactive oxygen species and decreased microvascular...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: Pang, Paul, Abbott, Molly, Abdi, Malyun, Fucci, Quynh-Anh, Chauhan, Nikita, Mistri, Murti, Proctor, Brandon, Chin, Matthew, Wang, Bin, Yin, Wenqing, Lu, Tzong-Shi, Halim, Arvin, Lim, Kenneth, Handy, Diane E, Loscalzo, Joseph, Siedlecki, Andrew M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982720/
https://ncbi.nlm.nih.gov/pubmed/29244159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfx304
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