AMINOGLYCOSIDES DECREASE GLUTATHIONE PEROXIDASE-1 ACTIVITY BY INTERFERING WITH SELENOCYSTEINE INCORPORATION

Cellular glutathione peroxidase is a key intracellular antioxidant enzyme that contains a selenocysteine residue at its active site. Selenium, a selenocysteine-incorporation sequence in the 3′- untranslated region of the glutathione peroxidase mRNA, and other translational cofactors are necessary fo...

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Hlavní autoři: Handy, Diane E., Hang, Gaozhen, Scolaro, John, Metes, Nicole, Razaq, Nadia, Yang, Yi, Loscalzo, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472404/
https://ncbi.nlm.nih.gov/pubmed/16354666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M511295200
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