Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses

Glutathione peroxidase-1 (GPx-1) is a selenocysteine-containing enzyme that plays a major role in the reductive detoxification of peroxides in cells. In permanently transfected cells with approximate 2-fold overexpression of GPx-1, we found that intracellular accumulation of oxidants in response to...

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Autors principals: Handy, Diane E., Lubos, Edith, Yang, Yi, Galbraith, John D., Kelly, Neil, Zhang, Ying-Yi, Leopold, Jane A., Loscalzo, Joseph
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673260/
https://ncbi.nlm.nih.gov/pubmed/19254950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900392200
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