Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation

Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant enzyme, the deficiency of which promotes atherogenesis. Accordingly, we examined the mechanisms by which GPx-1 deficiency enhances endothelial cell activation and inflammation. In human microvascular endothelial cells, we found that GPx-1 def...

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Bibliografiske detaljer
Main Authors: Lubos, Edith, Kelly, Neil J., Oldebeken, Scott R., Leopold, Jane A., Zhang, Ying-Yi, Loscalzo, Joseph, Handy, Diane E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195617/
https://ncbi.nlm.nih.gov/pubmed/21852236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205708
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