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Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survival
We investigated the effects of tumor necrosis factor-α (TNF-α) exposure on mitogen-activated protein kinase signalling in human microvascular endothelial cells. TNF-α caused a significant suppression of a dual specificity phosphatase, DUSP4, that regulates ERK1/2 activation. Thus, we hypothesized th...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3772965/ https://ncbi.nlm.nih.gov/pubmed/23812841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-013-1730-7 |
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