Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survival

We investigated the effects of tumor necrosis factor-α (TNF-α) exposure on mitogen-activated protein kinase signalling in human microvascular endothelial cells. TNF-α caused a significant suppression of a dual specificity phosphatase, DUSP4, that regulates ERK1/2 activation. Thus, we hypothesized th...

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Main Authors: Kao, Derrick D., Oldebeken, Scott R., Rai, Anjali, Lubos, Edith, Leopold, Jane A., Loscalzo, Joseph, Handy, Diane E.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772965/
https://ncbi.nlm.nih.gov/pubmed/23812841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-013-1730-7
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