Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

Thiopurines (eg, 6-mercaptopurine [MP]) are highly efficacious antileukemic agents, but they are also associated with dose-limiting toxicities. Recent studies by us and others have identified inherited NUDT15 deficiency as a novel genetic cause of thiopurine toxicity, and there is a strong rationale...

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書誌詳細
出版年:Blood
主要な著者: Nishii, Rina, Moriyama, Takaya, Janke, Laura J., Yang, Wenjian, Suiter, Chase C., Lin, Ting-Nien, Li, Lie, Kihira, Kentaro, Toyoda, Hidemi, Hofmann, Ute, Schwab, Matthias, Takagi, Masatoshi, Morio, Tomohiro, Manabe, Atsushi, Kham, Shirley, Jiang, Nan, Rabin, Karen R., Kato, Motohiro, Koh, Katsuyoshi, Yeoh, Allen Eng-Juh, Hori, Hiroki, Yang, Jun J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2018
主題:
Lymphoid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981167/
https://ncbi.nlm.nih.gov/pubmed/29572377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-11-815506
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