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Oxycodone‐induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition

BACKGROUND AND PURPOSE: Oxycodone, a prescription opioid, is a major drug of abuse, especially in the USA, and contributes significantly to opioid overdose deaths each year. Overdose deaths result primarily from respiratory depression. We have studied respiratory depression by oxycodone and have cha...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Hill, Rob, Dewey, William L, Kelly, Eamonn, Henderson, Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980627/
https://ncbi.nlm.nih.gov/pubmed/29574756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14219
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