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Oxycodone‐induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition

BACKGROUND AND PURPOSE: Oxycodone, a prescription opioid, is a major drug of abuse, especially in the USA, and contributes significantly to opioid overdose deaths each year. Overdose deaths result primarily from respiratory depression. We have studied respiratory depression by oxycodone and have cha...

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Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Hill, Rob, Dewey, William L, Kelly, Eamonn, Henderson, Graeme
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980627/
https://ncbi.nlm.nih.gov/pubmed/29574756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14219
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