PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

Background: Chemotherapy is currently evaluated in order to enhance the efficacy of immune checkpoint blockade (ICB) therapy in colorectal cancer. However, the mechanisms by which these drugs could synergize with ICB remains unclear. The impact of chemotherapy on the PD-1/PD-L1 pathway and the resul...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Dosset, Magalie, Vargas, Thaiz Rivera, Lagrange, Anaïs, Boidot, Romain, Végran, Frédérique, Roussey, Aurélie, Chalmin, Fanny, Dondaine, Lucile, Paul, Catherine, Lauret Marie-Joseph, Elodie, Martin, François, Ryffel, Bernhard, Borg, Christophe, Adotévi, Olivier, Ghiringhelli, François, Apetoh, Lionel
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980491/
https://ncbi.nlm.nih.gov/pubmed/29872568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1433981
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