Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of T(H)9 cells

Autophagy, a catabolic mechanism that involves degradation of cellular components, is essential for cell homeostasis. Although autophagy favours the lineage stability of regulatory T cells, the contribution of autophagy to the differentiation of effector CD4 T cells remains unclear. Here we show tha...

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Publicat a:Nat Commun
Autors principals: Rivera Vargas, Thaiz, Cai, Zhijian, Shen, Yingying, Dosset, Magalie, Benoit-Lizon, Isis, Martin, Tiffany, Roussey, Aurélie, Flavell, Richard A., Ghiringhelli, François, Apetoh, Lionel
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602674/
https://ncbi.nlm.nih.gov/pubmed/28916785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00468-w
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