In vivo effects of μ‐opioid receptor agonist/δ‐opioid receptor antagonist peptidomimetics following acute and repeated administration

BACKGROUND AND PURPOSE: Agonists at μ‐opioid receptors (μ‐receptors) are used for pain management but produce adverse effects including tolerance, dependence and euphoria. The co‐administration of a μ‐receptor agonist with a δ‐opioid receptor (δ‐receptor) antagonist has been shown to produce antinoc...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Anand, Jessica P, Kochan, Kelsey E, Nastase, Anthony F, Montgomery, Deanna, Griggs, Nicholas W, Traynor, John R, Mosberg, Henry I, Jutkiewicz, Emily M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5978946/
https://ncbi.nlm.nih.gov/pubmed/29352503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14148
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