Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9

The accumulating evidence demonstrates that Syrian hamsters have advantages as models for various diseases. To develop a Syrian hamster (Mesocricetus auratus) model of human immunodeficiency caused by RAG1 gene mutations, we employed the CRISPR/Cas9 system and introduced an 86-nucleotide frameshift...

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Veröffentlicht in:Viruses
Hauptverfasser: Miao, Jinxin, Ying, Baoling, Li, Rong, Tollefson, Ann E., Spencer, Jacqueline F., Wold, William S. M., Song, Seok-Hwan, Kong, Il-Keun, Toth, Karoly, Wang, Yaohe, Wang, Zhongde
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977236/
https://ncbi.nlm.nih.gov/pubmed/29734775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v10050243
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