STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control

Human adenoviruses have been studied extensively in cell culture and have been a model for studies in molecular, cellular, and medical biology. However, much less is known about adenovirus replication and pathogenesis in vivo in a permissive host because of the lack of an adequate animal model. Pres...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:PLoS Pathog
المؤلفون الرئيسيون: Toth, Karoly, Lee, Sang R., Ying, Baoling, Spencer, Jacqueline F., Tollefson, Ann E., Sagartz, John E., Kong, Il-Keun, Wang, Zhongde, Wold, William S. M.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2015
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546297/
https://ncbi.nlm.nih.gov/pubmed/26291525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005084
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