The MR-Base platform supports systematic causal inference across the human phenome

Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR methods are evolving rapidly and GWAS results are often...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:eLife
Κύριοι συγγραφείς: Hemani, Gibran, Zheng, Jie, Elsworth, Benjamin, Wade, Kaitlin H, Haberland, Valeriia, Baird, Denis, Laurin, Charles, Burgess, Stephen, Bowden, Jack, Langdon, Ryan, Tan, Vanessa Y, Yarmolinsky, James, Shihab, Hashem A, Timpson, Nicholas J, Evans, David M, Relton, Caroline, Martin, Richard M, Davey Smith, George, Gaunt, Tom R, Haycock, Philip C
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: eLife Sciences Publications, Ltd 2018
Θέματα:
Computational and Systems Biology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976434/
https://ncbi.nlm.nih.gov/pubmed/29846171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34408
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