Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regimens, which can lead to fatal side-effects. In addit...

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發表在:PLoS Negl Trop Dis
Main Authors: Steketee, Pieter C., Vincent, Isabel M., Achcar, Fiona, Giordani, Federica, Kim, Dong-Hyun, Creek, Darren J., Freund, Yvonne, Jacobs, Robert, Rattigan, Kevin, Horn, David, Field, Mark C., MacLeod, Annette, Barrett, Michael P.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976210/
https://ncbi.nlm.nih.gov/pubmed/29758036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006450
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