CDK4/6 inhibitors sensitize Rb-positive sarcoma cells to Wee1 kinase inhibition through reversible cell cycle arrest

Research into the biology of soft tissue sarcomas has uncovered very few effective treatment strategies that improve upon the current standard of care which usually involves surgery, radiation, and chemotherapy. Many patients with large (>5cm), high-grade sarcomas develop recurrence, and at that...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Francis, Ashleigh M., Alexander, Angela, Liu, Yanna, Vijayaraghavan, Smruthi, Low, Kwang Hui, Yang, Dong, Bui, Tuyen, Somaiah, Neeta, Ravi, Vinod, Keyomarsi, Khandan, Hunt, Kelly K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975955/
https://ncbi.nlm.nih.gov/pubmed/28619757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0040
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