Hepatitis C Virus Mimics Effects of Glypican-3 on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes

Glypican (GPC)-3 is overexpressed in hepatocellular carcinomas (HCCs). GPC3 binds to CD81. Forced expression of CD81 in a GPC3-expressing HCC cell line caused activation of Hippo, a decrease in ezrin phosphorylation, and a decrease in yes-associated protein (YAP). CD81 is also associated with hepati...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Xue, Yuhua, Mars, Wendy M., Bowen, William, Singhi, Aatur D., Stoops, John, Michalopoulos, George K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975625/
https://ncbi.nlm.nih.gov/pubmed/29577937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.02.013
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