Serum-Derived Hepatitis C Virus Infection of Primary Human Hepatocytes Is Tetraspanin CD81 Dependent

Hepatitis C virus-positive serum (HCVser, genotypes 1a to 3a) or HCV cell culture (JFH1/HCVcc) infection of primary normal human hepatocytes was assessed by measuring intracellular HCV RNA strands. Anti-CD81 antibodies and siRNA-CD81 silencing markedly inhibited (>90%) HCVser infection irrespecti...

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Main Authors: Molina, Sonia, Castet, Valerie, Pichard-Garcia, Lydiane, Wychowski, Czeslaw, Meurs, Eliane, Pascussi, Jean-Marc, Sureau, Camille, Fabre, Jean-Michel, SaCunha, Antonio, Larrey, Dominique, Dubuisson, Jean, Coste, Joliette, McKeating, Jane, Maurel, Patrick, Fournier-Wirth, Chantal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224376/
https://ncbi.nlm.nih.gov/pubmed/17942559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01443-07
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