Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway

Microglial NADPH oxidase (Nox2) plays a key role in chronic neuroinflammation and related dopaminergic neurodegeneration in Parkinson's disease (PD). However, the mechanisms behind Nox2 activation remain unclear. Here, we revealed the critical role of complement receptor 3 (CR3), a microglia-sp...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Hou, Liyan, Wang, Ke, Zhang, Cong, Sun, Fuqiang, Che, Yuning, Zhao, Xiulan, Zhang, Dan, Li, Huihua, Wang, Qingshan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975223/
https://ncbi.nlm.nih.gov/pubmed/28978491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.09.017
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