A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes

Trypanosoma brucei glutaredoxin 2 (Grx2) is a dithiol glutaredoxin that is specifically located in the mitochondrial intermembrane space. Bloodstream form parasites lacking Grx2 or both, Grx2 and the cytosolic Grx1, are viable in vitro and infectious to mice suggesting that neither oxidoreductase is...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Ebersoll, Samantha, Musunda, Blessing, Schmenger, Torsten, Dirdjaja, Natalie, Bonilla, Mariana, Manta, Bruno, Ulrich, Kathrin, Comini, Marcelo A., Krauth-Siegel, R. Luise
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975080/
https://ncbi.nlm.nih.gov/pubmed/29413965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.01.011
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