The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages

Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response to bacterial infection. Salmonella typhimurium can invade macrophages and proliferate in th...

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Udgivet i:Nat Commun
Main Authors: Lim, Daejin, Kim, Kwang Soo, Jeong, Jae-Ho, Marques, Oriana, kim, Hyun-Ju, Song, Miryoung, Lee, Tae-Hoon, Kim, Jae Il, Choi, Hueng-Sik, Min, Jung-Joon, Bumann, Dirk, Muckenthaler, Martina U., Choy, Hyon E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974375/
https://ncbi.nlm.nih.gov/pubmed/29844422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04446-8
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