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The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response to bacterial infection. Salmonella typhimurium can invade macrophages and proliferate in th...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5974375/ https://ncbi.nlm.nih.gov/pubmed/29844422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04446-8 |
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