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Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2
KCNH2 encodes the Kv11.1 α-subunit that underlies the rapidly activating delayed-rectifier K(+) current in the heart. Loss-of-function KCNH2 mutations cause long QT syndrome type 2 (LQT2), and most LQT2-linked missense mutations inhibit the trafficking of Kv11.1 channel protein to the cell surface m...
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| Yayımlandı: | Front Physiol |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Frontiers Media S.A.
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5974211/ https://ncbi.nlm.nih.gov/pubmed/29875689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00584 |
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