Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pERK Signaling

Pericytes are one of the principal sources of scar-forming myofibroblasts in chronic kidneys disease. However, the modulation of pericyte-to-myofibroblast transdifferentiation (PMT) in the early phases of acute kidney injury is poorly understood. Here, we investigated the role of complement in induc...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Castellano, Giuseppe, Franzin, Rossana, Stasi, Alessandra, Divella, Chiara, Sallustio, Fabio, Pontrelli, Paola, Lucarelli, Giuseppe, Battaglia, Michele, Staffieri, Francesco, Crovace, Antonio, Stallone, Giovanni, Seelen, Marc, Daha, Mohamed R., Grandaliano, Giuseppe, Gesualdo, Loreto
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974049/
https://ncbi.nlm.nih.gov/pubmed/29875766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01002
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