Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

In many malignancies, the tumor microenvironment includes CSF1R-expressing supportive monocyte/macrophages that promote tumor cell survival. For chronic lymphocytic leukemia (CLL), these supportive monocyte/macrophages are known as nurse-like cells (NLCs), although the potential effectiveness of sel...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Edwards V, David K., Sweeney, David Tyler, Ho, Hibery, Eide, Christopher A., Rofelty, Angela, Agarwal, Anupriya, Liu, Selina Qiuying, Danilov, Alexey V., Lee, Patrice, Chantry, David, McWeeney, Shannon K., Druker, Brian J., Tyner, Jeffrey W., Spurgeon, Stephen E., Loriaux, Marc M.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2018
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973855/
https://ncbi.nlm.nih.gov/pubmed/29872489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25191
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