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CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

To identify new therapeutic targets in acute myeloid leukemia (AML), we performed small-molecule and small-interfering RNA (siRNA) screens of primary AML patient samples. In 23% of samples, we found sensitivity to inhibition of colony-stimulating factor 1 (CSF1) receptor (CSF1R), a receptor tyrosine...

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書目詳細資料
發表在:Blood
Main Authors: Edwards, David K., Watanabe-Smith, Kevin, Rofelty, Angela, Damnernsawad, Alisa, Laderas, Ted, Lamble, Adam, Lind, Evan F., Kaempf, Andy, Mori, Motomi, Rosenberg, Mara, d’Almeida, Amanda, Long, Nicola, Agarwal, Anupriya, Sweeney, David Tyler, Loriaux, Marc, McWeeney, Shannon K., Tyner, Jeffrey W.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367650/
https://ncbi.nlm.nih.gov/pubmed/30425048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-838946
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