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CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells
To identify new therapeutic targets in acute myeloid leukemia (AML), we performed small-molecule and small-interfering RNA (siRNA) screens of primary AML patient samples. In 23% of samples, we found sensitivity to inhibition of colony-stimulating factor 1 (CSF1) receptor (CSF1R), a receptor tyrosine...
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發表在: | Blood |
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Main Authors: | , , , , , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
American Society of Hematology
2019
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6367650/ https://ncbi.nlm.nih.gov/pubmed/30425048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-838946 |
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