ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase

Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aars(sti) mutant mice resulted in an increased production of serine-mischarged tRNA(Ala) and degeneration of cerebellar...

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Publicat a:Nature
Autors principals: Vo, My-Nuong, Terrey, Markus, Lee, Jeong Woong, Roy, Bappaditya, Moresco, James J., Sun, Litao, Fu, Hongjun, Liu, Qi, Weber, Thomas G., Yates, John R., Fredrick, Kurt, Schimmel, Paul, Ackerman, Susan L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973781/
https://ncbi.nlm.nih.gov/pubmed/29769718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0137-8
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