Dissociating Quaternary Structure Regulates Cell-signaling Functions of a Secreted Human tRNA Synthetase

Many tRNA synthetases are homodimers that are catalytically inactive as monomers. An example is the 528-amino acid human tyrosyl-tRNA synthetase, which is made up of an N-terminal catalytic unit (TyrRS(Mini)) and a 164-amino acid C-domain. Although native TyrRS has no known cytokine functions, natur...

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Bibliographic Details
Main Authors: Vo, My-Nuong, Yang, Xiang-Lei, Schimmel, Paul
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064210/
https://ncbi.nlm.nih.gov/pubmed/21310955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.213876
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