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Dissociating Quaternary Structure Regulates Cell-signaling Functions of a Secreted Human tRNA Synthetase
Many tRNA synthetases are homodimers that are catalytically inactive as monomers. An example is the 528-amino acid human tyrosyl-tRNA synthetase, which is made up of an N-terminal catalytic unit (TyrRS(Mini)) and a 164-amino acid C-domain. Although native TyrRS has no known cytokine functions, natur...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064210/ https://ncbi.nlm.nih.gov/pubmed/21310955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.213876 |
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