HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs

HIV-1 downregulates human leukocyte antigen A (HLA-A) and HLA-B from the surface of infected cells primarily to evade CD8 T cell recognition. HLA-C was thought to remain on the cell surface and bind inhibitory killer immunoglobulin-like receptors, preventing natural killer (NK) cell-mediated suppres...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ende, Zachary, Deymier, Martin J., Claiborne, Daniel T., Prince, Jessica L., Mónaco, Daniela C., Kilembe, William, Allen, Susan A., Hunter, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972908/
https://ncbi.nlm.nih.gov/pubmed/29321314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01633-17
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