Therapeutic Efficacy of Vectored PGT121 Gene Delivery in HIV-1-Infected Humanized Mice

Broadly neutralizing antibodies (bNAbs) are being explored for HIV-1 prevention and cure strategies. However, administration of purified bNAbs poses challenges in resource-poor settings, where the HIV-1 disease burden is greatest. In vivo vector-based production of bNAbs represents an alternative st...

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Veröffentlicht in:J Virol
Hauptverfasser: Badamchi-Zadeh, Alexander, Tartaglia, Lawrence J., Abbink, Peter, Bricault, Christine A., Liu, Po-Ting, Boyd, Michael, Kirilova, Marinela, Mercado, Noe B., Nanayakkara, Ovini S., Vrbanac, Vladimir D., Tager, Andrew M., Larocca, Rafael A., Seaman, Michael S., Barouch, Dan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972893/
https://ncbi.nlm.nih.gov/pubmed/29321310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01925-17
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