Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)

Tuberculosis is still a leading cause of morbidity and mortality worldwide. Improvements to existing drug regimens and the development of novel therapeutics are urgently required. The ability of dosed TB drugs to reach and sterilize bacteria within poorly-vascularized necrotic regions (caseum) of pu...

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Spremljeno u:
Bibliografski detalji
Izdano u:J Vis Exp
Glavni autori: Zimmerman, Matthew, Blanc, Landry, Chen, Pei-Yu, Dartois, Véronique, Prideaux, Brendan
Format: Artigo
Jezik:Inglês
Izdano: MyJove Corporation 2018
Teme:
Medicine
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972363/
https://ncbi.nlm.nih.gov/pubmed/29733325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/57402
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