Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection

Group A Streptococcus (GAS) is an important human pathogen that causes a wide spectrum of diseases, including necrotizing fasciitis and streptococcal toxic shock syndrome. Dextromethorphan (DM), an antitussive drug, has been demonstrated to efficiently reduce inflammatory responses, thereby contribu...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chen, Chia-Ling, Cheng, Miao-Huei, Kuo, Chih-Feng, Cheng, Yi-Lin, Li, Ming-Han, Chang, Chih-Peng, Wu, Jiunn-Jong, Anderson, Robert, Wang, Shuying, Tsai, Pei-Jane, Liu, Ching-Chuan, Lin, Yee-Shin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
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Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971618/
https://ncbi.nlm.nih.gov/pubmed/29581121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02045-17
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