Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection

Group A Streptococcus (GAS) is an important human pathogen that causes a wide spectrum of diseases, including necrotizing fasciitis and streptococcal toxic shock syndrome. Dextromethorphan (DM), an antitussive drug, has been demonstrated to efficiently reduce inflammatory responses, thereby contribu...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Antimicrob Agents Chemother
Κύριοι συγγραφείς: Chen, Chia-Ling, Cheng, Miao-Huei, Kuo, Chih-Feng, Cheng, Yi-Lin, Li, Ming-Han, Chang, Chih-Peng, Wu, Jiunn-Jong, Anderson, Robert, Wang, Shuying, Tsai, Pei-Jane, Liu, Ching-Chuan, Lin, Yee-Shin
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2018
Θέματα:
Mechanisms of Action: Physiological Effects
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971618/
https://ncbi.nlm.nih.gov/pubmed/29581121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02045-17
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