Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

AB-423 is a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors in phase 1 clinical trials. In cell culture models, AB-423 showed potent inhibition of HBV replication (50% effective concentration [EC(50)] = 0.08 to 0.27 μM; EC(90) = 0.33 to 1.32 μM) with no sign...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Cobarrubias, Kyle D., Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O., Kadhim, Salam, Kultgen, Steven G., Lee, Amy C. H., Li, Alice H. L., Long, Quanxin, Majeski, Sara A., Mao, Richeng, McClintock, Kevin D., Reid, Stephen P., Rijnbrand, Rene, Snead, Nicholas M., Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2018
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971612/
https://ncbi.nlm.nih.gov/pubmed/29555628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00082-18
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