Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

AB-423 is a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors in phase 1 clinical trials. In cell culture models, AB-423 showed potent inhibition of HBV replication (50% effective concentration [EC(50)] = 0.08 to 0.27 μM; EC(90) = 0.33 to 1.32 μM) with no sign...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Cobarrubias, Kyle D., Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O., Kadhim, Salam, Kultgen, Steven G., Lee, Amy C. H., Li, Alice H. L., Long, Quanxin, Majeski, Sara A., Mao, Richeng, McClintock, Kevin D., Reid, Stephen P., Rijnbrand, Rene, Snead, Nicholas M., Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2018
Ábhair:
Antiviral Agents
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971612/
https://ncbi.nlm.nih.gov/pubmed/29555628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00082-18
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