Acute loss of iron–sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells

Iron–sulfur (Fe-S) clusters are ancient cofactors in cells and participate in diverse biochemical functions, including electron transfer and enzymatic catalysis. Although cell lines derived from individuals carrying mutations in the Fe-S cluster biogenesis pathway or siRNA-mediated knockdown of the...

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Publicado no:J Biol Chem
Main Authors: Crooks, Daniel R., Maio, Nunziata, Lane, Andrew N., Jarnik, Michal, Higashi, Richard M., Haller, Ronald G., Yang, Ye, Fan, Teresa W-M., Linehan, W. Marston, Rouault, Tracey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971457/
https://ncbi.nlm.nih.gov/pubmed/29523684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001885
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