SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

BACKGROUND: Mutations in the Fe-S cluster-containing SDHB subunit of succinate dehydrogenase cause familial cancer syndromes. Recently the tripeptide motif L(I)YR was identified in the Fe-S recipient protein SDHB, to which the cochaperone HSC20 binds. METHODS: In order to characterize the metabolic...

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Publicat a:J Natl Cancer Inst
Autors principals: Saxena, Neetu, Maio, Nunziata, Crooks, Daniel R., Ricketts, Christopher J., Yang, Youfeng, Wei, Ming-Hui, Fan, Teresa W-M., Lane, Andrew N., Sourbier, Carole, Singh, Anamika, Killian, J. Keith, Meltzer, Paul S., Vocke, Cathy D., Rouault, Tracey A., Linehan, W. Marston
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732025/
https://ncbi.nlm.nih.gov/pubmed/26719882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv287
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