TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well understood. Here, we describe TRAF6 as an essential regulator of HSC homeostasis through basal a...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Fang, Jing, Muto, Tomoya, Kleppe, Maria, Bolanos, Lyndsey C., Hueneman, Kathleen M., Walker, Callum S., Sampson, Leesa, Wellendorf, Ashley M., Chetal, Kashish, Choi, Kwangmin, Salomonis, Nathan, Choi, Yongwon, Zheng, Yi, Cancelas, Jose A., Levine, Ross L., Starczynowski, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971064/
https://ncbi.nlm.nih.gov/pubmed/29386112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.013
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