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Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and progenitor cells (HSPCs), the mechanisms responsible for the competitive advantage of MDS HSPCs in an inflammatory milieu ov...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Immunol
Hauptverfasser: Muto, Tomoya, Walker, Callum S., Choi, Kwangmin, Hueneman, Kathleen, Smith, Molly A., Gul, Zartash, Garica-Manero, Guillermo, Ma, Averil, Zheng, Yi, Statczynowski, Daniel T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402480/
https://ncbi.nlm.nih.gov/pubmed/32313245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0663-z
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