Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis

Accumulating evidence has suggested that farnesoid X receptor (FXR) agonists, such as obeticholic acid (OCA) are therapeutically useful for non-alcoholic steatohepatitis (NASH). However, it is still unclear how FXR agonists protect against NASH and which cell type is the main target of FXR agonists....

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Publicado no:Sci Rep
Main Authors: Goto, Toshihiro, Itoh, Michiko, Suganami, Takayoshi, Kanai, Sayaka, Shirakawa, Ibuki, Sakai, Takeru, Asakawa, Masahiro, Yoneyama, Toshihiro, Kai, Toshihiro, Ogawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970222/
https://ncbi.nlm.nih.gov/pubmed/29802399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26383-8
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