CD11c(+) resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis

Although recent evidence has pointed to the role of organ- and pathogenesis-specific macrophage subsets, it is still unclear which subsets are critically involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). Using melanocortin-4 receptor–deficient (MC4R-KO) mice fed Western diet (WD),...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Itoh, Michiko, Suganami, Takayoshi, Kato, Hideaki, Kanai, Sayaka, Shirakawa, Ibuki, Sakai, Takeru, Goto, Toshihiro, Asakawa, Masahiro, Hidaka, Isao, Sakugawa, Hiroshi, Ohnishi, Koji, Komohara, Yoshihiro, Asano, Kenichi, Sakaida, Isao, Tanaka, Masato, Ogawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752377/
https://ncbi.nlm.nih.gov/pubmed/29202448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92902
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